GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs13168670 | 1 | rs13168670 | chr5:140146899 | WDR55 | chr5:140044384-140050551:+ | -0.18 | -5.01 | 6.26E-7 | Schizophrenia |
| BRCA | cis | rs13168670 | 1 | rs13168670 | chr5:140146899 | ZMAT2 | chr5:140080032-140086239:+ | -0.17 | -5.05 | 5.17E-7 | Schizophrenia |
| BRCA | cis | rs2036402 | 1 | rs13169155 | chr5:156426663 | TIMD4 | chr5:156346293-156390266:- | -0.15 | -4.06 | 5.25E-5 | Hypertriglyceridemia |
| BRCA | cis | rs2036402 | 1 | rs13169465 | chr5:156426916 | TIMD4 | chr5:156346293-156390266:- | -0.15 | -3.89 | 0.000109 | Hypertriglyceridemia |
| BRCA | cis | rs2036402 | 1 | rs13169621 | chr5:156426974 | TIMD4 | chr5:156346293-156390266:- | -0.16 | -4.16 | 3.37E-5 | Hypertriglyceridemia |
| BRCA | cis | rs7927771 | 1 | rs1317149 | chr11:47486885 | ACP2 | chr11:47260854-47270457:- | 0.13 | 3.42 | 0.00065 | Subjective well-being |
| BRCA | cis | rs7927771 | 1 | rs1317149 | chr11:47486885 | MADD | chr11:47290927-47351582:+ | 0.14 | 4.3 | 1.87E-5 | Subjective well-being |
| BRCA | cis | rs7927771 | 1 | rs1317149 | chr11:47486885 | MYBPC3 | chr11:47352958-47374253:- | -0.15 | -4.38 | 1.31E-5 | Subjective well-being |
| BRCA | cis | rs470119 | 1 | rs131801 | chr22:50966634 | SCO2 | chr22:50961999-50964034:- | -0.19 | -7.22 | 1.02E-12 | Mean corpuscular hemoglobin |
| BRCA | cis | rs2036402 | 1 | rs13181803 | chr5:156429177 | TIMD4 | chr5:156346293-156390266:- | -0.16 | -4.21 | 2.74E-5 | Hypertriglyceridemia |
| BRCA | cis | rs1061377 | 1 | rs13182 | chr4:39122913 | KLHL5 | chr4:39046659-39123828:+ | -0.15 | -4.65 | 3.8E-6 | Uric acid levels |
| BRCA | cis | rs13182402 | 1 | rs13182402 | chr5:125918148 | ALDH7A1 | chr5:125878918-125931082:- | -0.19 | -3.65 | 0.00028 | Osteoporosis |
| BRCA | cis | rs13182402 | 1 | rs13182402 | chr5:125918148 | PHAX | chr5:125936633-125961080:+ | -0.14 | -3.56 | 0.000383 | Osteoporosis |
| BRCA | cis | rs13191362 | 1 | rs13190742 | chr6:163008758 | PACRG | chr6:163148164-163736523:+ | 0.23 | 4.37 | 1.36E-5 | Body mass index |
| BRCA | cis | rs13191362 | 1 | rs13191362 | chr6:163033350 | PACRG | chr6:163148164-163736523:+ | 0.23 | 4.09 | 4.64E-5 | Body mass index |